Heineman H S, Breen F A
Cancer. 1975 Oct;36(4):1344-7. doi: 10.1002/1097-0142(197510)36:4<1344::aid-cncr2820360423>3.0.co;2-9.
Herpes simplex encephalitis developed in a patient with Hodgkin's disease under therapy. Despite treatment with idoxuridine in a total dose of 280 mg/kg intravenously, he died without showing any clinical response. At autopsy, there was no gross or microscopic evidence of Hodgkin's disease, and virus isolated from the brain postmortem was inhibited in vitro by idoxuridine 0.5 mug/ml. Failure of idoxuridine to affect the course of infection by a drug-sensitive virus may be due to poor tissue penetration, although the role of the Hodgkin's disease cannot be discounted.
一名正在接受治疗的霍奇金病患者发生了单纯疱疹性脑炎。尽管静脉注射了总量为280mg/kg的碘苷进行治疗，但他仍未出现任何临床反应而死亡。尸检时，未发现霍奇金病的大体或显微镜下证据，死后从大脑中分离出的病毒在体外被0.5μg/ml的碘苷抑制。碘苷未能影响对药物敏感病毒的感染过程，可能是由于组织穿透力差，尽管霍奇金病的作用也不能忽视。
