Warembourg M
Cell Tissue Res. 1975 Aug 18;161(2):183-91. doi: 10.1007/BF00220367.
The central nervous system and the pituitary of adrenalectomized male rats injected with 3H-dexamethasone were examined by radioautography. At 1 hr after the injection, radioactivity concentration was high in the medial basal hypothalamus, the pituitary and the pineal gland. In the hypothalamus, radioactive material was found to be selectively concentrated in neurons in the ventral part of nucleus arcuatus and in the infundibular region. In the anterior pituitary, a large proportion of cells showed silver grains both in the cytoplasm and over the cell nuclei. However, in a small number of cells, the radioactive material was associated with the cell nuclei. Less radioactivity was present in the intermediate and posterior lobes. The pineal gland contained more silver grains than did other regions of the brain. The results obtained in the present study suggest essentially an action of dexamethasone in the medial basal hypothalamus and at the level of the pituitary.
通过放射自显影术对注射了3H-地塞米松的去肾上腺雄性大鼠的中枢神经系统和垂体进行了检查。注射后1小时，内侧基底下丘脑、垂体和松果体中的放射性浓度较高。在下丘脑中，放射性物质被发现选择性地集中在弓状核腹侧部分和漏斗区域的神经元中。在垂体前叶，大部分细胞的细胞质和细胞核上都显示有银颗粒。然而，在少数细胞中，放射性物质与细胞核相关。中间叶和后叶中的放射性较少。松果体中的银颗粒比大脑的其他区域更多。本研究获得的结果基本上表明地塞米松在内侧基底下丘脑和垂体水平发挥作用。
