Keld Dorte Bülow, Hahn Thomas
Arhus Universitetshospital, Aalborg Sygehus Syd, Anaestesisektor Nordjylland, Intensiv Afdeling R, 4. afdeling.
Ugeskr Laeger. 2006 Sep 11;168(37):3121-4.
The goal of this study was to investigate the use and side effects of anabolic androgenic steroids (AASs), growth hormone (GH), erythropoietin (EPO) and other enhancing drugs by patients in general practice.
In a questionnaire, 702 general practitioners (GPs) in Denmark were asked to estimate the number of their patients who within the preceding year had admitted to using or were highly suspected of having used AASs, GH, EPO or other enhancing drugs. In addition, they were asked to describe the possible side effects of their use.
Of 571 eligible GPs, 119 had within the preceding year treated patients who had admitted to or were highly suspected of having used AASs, GH, EPO or other enhancing drugs. 182 users were reported by the GPs during that period; 180 (99%) were males, and 156 (86%) were between 20 and 40 years of age. 125 of the patients (69%) had admitted the use to the GP; AASs had been used by 123 patients (98%). EPO was not reported in any case, but GH had been used by 9 patients (7%). 127 (70%) of the patients had experienced side effects, and 87 (49%) had contacted the GP due to these side effects.
The use and side effects of AAS are commonly reported in general practice, whereas the use and side effects of GH and EPO seem to be uncommon. Their use is mainly by men under 40 years of age. The use of AAS is often connected with dermatological and musculoskeletal side effects. It is recommended also to consider possible use of AASs when consulted by a patient with unexplained symptoms of cardiovascular disease, psychological or sexual dysfunction, gynaecomastia or liver dysfunction.
本研究的目的是调查全科医疗中患者使用合成代谢雄激素类固醇(AAS)、生长激素(GH)、促红细胞生成素(EPO)及其他增强药物的情况和副作用。
在一份调查问卷中,丹麦的702名全科医生被要求估算在前一年中承认使用或被高度怀疑使用AAS、GH、EPO或其他增强药物的患者数量。此外,还要求他们描述使用这些药物可能产生的副作用。
在571名符合条件的全科医生中,有119名在前一年治疗过承认使用或被高度怀疑使用AAS、GH、EPO或其他增强药物的患者。在此期间,全科医生共报告了182名使用者;其中180名(99%)为男性,156名(86%)年龄在20至40岁之间。125名患者(69%)向全科医生承认了用药情况;123名患者(98%)使用了AAS。未报告有患者使用EPO,但有9名患者(7%)使用了GH。127名患者(70%)出现了副作用,其中87名(49%)因这些副作用联系过全科医生。
在全科医疗中,AAS的使用和副作用较为常见,而GH和EPO的使用及副作用似乎并不常见。其使用者主要是40岁以下的男性。AAS的使用常与皮肤和肌肉骨骼方面的副作用相关。当遇到有不明原因的心血管疾病、心理或性功能障碍、男性乳房发育或肝功能障碍症状的患者咨询时,也建议考虑其可能使用过AAS。