Petzold A, Hinds N, Murray N M F, Hirsch N P, Grant D, Keir G, Thompson E J, Reilly M M
Department of Neuroimmunology, Institute of Neurology and Tavistock Intensive Care Unit, National Hospital for Neurology and Neurosurgery, London, UK.
Neurology. 2006 Sep 26;67(6):1071-3. doi: 10.1212/01.wnl.0000237334.69665.92.
Long-term morbidity from Guillain-Barré syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (>0.73 ng/mL) predicted worse motor and functional outcome.
吉兰-巴雷综合征（GBS）的长期发病率由轴突损伤引起。这项前瞻性研究表明，作为轴突损伤生物标志物的神经丝（NfHs）在GBS中具有预后价值。脑脊液NfH水平与F评分和医学研究委员会综合评分相关，与无轴突变性神经生理学证据的患者相比，有轴突变性神经生理学证据的患者脑脊液NfH水平更高。脑脊液NfH水平病理性升高（>0.73 ng/mL）预示着运动和功能预后更差。
