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来自感染SIV/SMM的血清阳性临床无症状乌白眉猴的CD8+细胞对SIV/SMM体外复制的抑制作用

Inhibition of SIV/SMM replication in vitro by CD8+ cells from SIV/SMM infected seropositive clinically asymptomatic sooty mangabeys.

作者信息

Powell J D, Yehuda-Cohen T, Villinger F, McClure H M, Sell K W, Ahmed-Ansari A

机构信息

Department of Pathology and Laboratory Medicine, Winship Cancer Center, Atlanta, GA.

出版信息

J Med Primatol. 1990;19(3-4):239-49.

PMID:1700128
Abstract

Several investigators have demonstrated the ability of CD8+ T cells from HIV-1 infected humans and SIV infected rhesus macaques to inhibit viral replication in vitro. In this report we show that CD8+ cells from naturally SIV infected sooty mangabeys also have the ability to inhibit viral replication in vitro. In addition, initial experiments which seek to elucidate the mechanism and antigen specificity of CD8-mediated suppression are described.

摘要

几位研究人员已证明，来自感染HIV-1的人类和感染SIV的恒河猴的CD8+ T细胞在体外具有抑制病毒复制的能力。在本报告中，我们表明，来自自然感染SIV的乌黑白眉猴的CD8+细胞在体外也具有抑制病毒复制的能力。此外，还描述了旨在阐明CD8介导的抑制机制和抗原特异性的初步实验。

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引用本文的文献

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J Virol. 1998 Dec;72(12):10165-70. doi: 10.1128/JVI.72.12.10165-10170.1998.
2
Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques.在乌黑白眉猴和恒河猴中感染猿猴免疫缺陷病毒SIVmac239后出现的多种宿主反应和结果。
J Virol. 1998 Dec;72(12):9597-611. doi: 10.1128/JVI.72.12.9597-9611.1998.
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Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease.
猿猴免疫缺陷病毒在乌黑白眉猴体内大量复制，但不引发疾病。
J Virol. 1998 May;72(5):3872-86. doi: 10.1128/JVI.72.5.3872-3886.1998.
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Evidence for CD8+ antiviral activity in cats infected with feline immunodeficiency virus.感染猫免疫缺陷病毒的猫中CD8 +抗病毒活性的证据。
J Virol. 1996 Apr;70(4):2474-80. doi: 10.1128/JVI.70.4.2474-2480.1996.
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Inhibition of cellular activation of retroviral replication by CD8+ T cells derived from non-human primates.源自非人类灵长类动物的CD8 + T细胞对逆转录病毒复制的细胞活化的抑制作用。
Clin Exp Immunol. 1993 Mar;91(3):473-81. doi: 10.1111/j.1365-2249.1993.tb05927.x.
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