Sit Dede, Kadiroğlu Ali Kemal, Kayabaşi Hasan, Hoşoğlu Salih
Mikrobiyol Bul. 2006 Jul;40(3):289-90.
The aim of this study was to evaluate the brucellosis patients inhabiting in Mus province, in Eastern Anatolia of Turkey, retrospectively. The mean age of the patients (n: 87) was 38.1 +/- 12.4 years, and 45% of them were female. The transmission route was the consumption of unpasteurized fresh cheese (in 85%), and unboiled milk (in 45%). The most common symptoms were recorded as chills (89%), fever (87%), and arthralgia (81%). Splenomegaly (71%) and hepatomegaly (63%) were the predominant physical examination signs. Diagnosis was made based on the clinical features and positive Rose-Bengal test result (93%), however, blood cultures could not be performed due to insufficient laboratory equipment. In 92% of the patients at least one complication has been detected indicating delayed admission to the hospital, while the most common complications were sacroileitis (79%) and spondylitis (44%). Streptomycin+doxycyclin, streptomycin+doxycyclin+ ciprofloxacin, and streptomycin+doxycyclin+ rifampicin combination therapies were used in 62%, 24% and 14% of the patients, respectively, for six weeks, resulting with complete cure.
本研究旨在回顾性评估居住在土耳其东安纳托利亚穆斯省的布鲁氏菌病患者。患者平均年龄(n = 87)为38.1±12.4岁,其中45%为女性。传播途径为食用未巴氏消毒的新鲜奶酪(85%)和未煮沸的牛奶(45%)。最常见的症状为寒战(89%)、发热(87%)和关节痛(81%)。脾肿大(71%)和肝肿大(63%)是主要的体格检查体征。根据临床特征和阳性玫瑰红试验结果(93%)进行诊断,但由于实验室设备不足无法进行血培养。92%的患者至少检测到一种并发症,表明入院延迟,最常见的并发症是骶髂关节炎(79%)和脊柱炎(44%)。分别有62%、24%和14%的患者使用链霉素+强力霉素、链霉素+强力霉素+环丙沙星和链霉素+强力霉素+利福平联合治疗六周,最终完全治愈。