Moiseeva O M, Aleshina G M, Ivanova T G, Kokriakov V N, Shliakhto E V
Vestn Ross Akad Med Nauk. 2006(8):3-7.
The study revealed an increase in the serum levels of TGF-beta1 and the N-terminal peptide procollagen type III in patients with essential arterial hypertension (EAH), as well as an association between this increase and the duration of the disease, mean day arterial pressure profile, and left ventricular hypertrophy. An increased leukocyte functional activity is associated with disturbances in left ventricular diastolic function and an increase in TGF-beta1 serum concentration in EAH. The authors conclude that leukocytes participate in the development of myocardial hypertrophy and cardial fibrosis through the secretion of pro-inflammatory cytokines and peptide growth factors within the process of their activation.
该研究揭示，原发性高血压（EAH）患者血清中转化生长因子-β1（TGF-β1）和Ⅲ型前胶原N端肽水平升高，且这种升高与疾病持续时间、平均日间动脉压曲线以及左心室肥厚相关。白细胞功能活性增加与EAH患者左心室舒张功能障碍及TGF-β1血清浓度升高有关。作者得出结论，白细胞在其激活过程中通过分泌促炎细胞因子和肽生长因子参与心肌肥厚和心脏纤维化的发展。
