Díez J, Laviades C, Monreal I, Gil M J, Panizo A, Pardo J
Department of Internal Medicine, School of Medicine, University of Navarra, Pamplona, Spain.
Am J Cardiol. 1995 Nov 2;76(13):14D-17D. doi: 10.1016/s0002-9149(99)80486-x.
The serum concentrations of amino-terminal procollagen type III and carboxy-terminal procollagen type I-derived peptides, which have been proposed as useful markers of the tissue synthesis of collagen types III and type I, respectively, were abnormally increased in patients with essential hypertension and became normal after angiotensin-converting enzyme (ACE) inhibition. An association was found between baseline serum concentrations of these peptides and left ventricular hypertrophy, diastolic dysfunction, and ventricular arrhythmias in hypertensive patients. On the other hand, increased serum concentration of the carboxy-terminal procollagen type I-derived peptide was found in spontaneously hypertensive rats compared with normotensive Wistar-Kyoto control rats. An association was found between the serum concentration of this peptide and the extent of myocardial fibrosis and the hydroxyproline concentration in the left ventricle of spontaneously hypertensive rats. It is proposed that procollagen-derived peptides in serum may be markers of exaggerated collagen tissue synthesis involved in hypertensive myocardial fibrosis.
血清Ⅲ型前胶原氨基端肽和Ⅰ型前胶原羧基端肽的浓度分别被认为是Ⅲ型和Ⅰ型胶原组织合成的有用标志物，在原发性高血压患者中异常升高，在血管紧张素转换酶（ACE）抑制后恢复正常。在高血压患者中，发现这些肽的基线血清浓度与左心室肥厚、舒张功能障碍和室性心律失常之间存在关联。另一方面，与正常血压的Wistar-Kyoto对照大鼠相比，自发性高血压大鼠血清Ⅰ型前胶原羧基端肽浓度升高。在自发性高血压大鼠中，发现该肽的血清浓度与心肌纤维化程度和左心室羟脯氨酸浓度之间存在关联。有人提出，血清中前胶原衍生肽可能是参与高血压心肌纤维化的胶原组织合成过度的标志物。
