Pulido J A, del Hoyo N, Perez-Albarsanz M A
Department of Biochemistry and Molecular Biology, University of Alcalá, Alcalá de Henares-Madrid, Spain.
Life Sci. 1990;47(13):1099-107. doi: 10.1016/0024-3205(90)90168-q.
The influence of 0.5 mM gamma-hexachlorocyclohexane (gamma-HCH, lindane) on glucose transport has been investigated using the analog 3-O-methyl-D-(U-14C)glucose. The glucose uptake was lineal for at least 10 sec. Preincubation of dissociated brain cortex cells with lindane decreased the transport of glucose with respect to the controls. The treatment of brain cortex cells with other organochlorine compounds indicated that the alpha-, delta-HCH isomers and dieldrin reproduced the same inhibitory pattern, while beta-HCH and endrin were inactive. The total radioactivity incorporated into CO2 from (U-14C) glucose in the cerebral cortex is also inhibited by lindane in a time dependent manner.
已使用类似物3 - O - 甲基 - D -（U - 14C）葡萄糖研究了0.5 mMγ-六氯环己烷（γ- HCH，林丹）对葡萄糖转运的影响。葡萄糖摄取至少在10秒内呈线性。将解离的脑皮质细胞与林丹预孵育会降低相对于对照组的葡萄糖转运。用其他有机氯化合物处理脑皮质细胞表明，α-、δ- HCH异构体和狄氏剂呈现相同的抑制模式，而β- HCH和异狄氏剂则无活性。林丹还以时间依赖性方式抑制大脑皮质中（U - 14C）葡萄糖掺入CO2中的总放射性。
