Bhattacharyya Neil
Division of Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Laryngoscope. 2006 Oct;116(10):1805-8. doi: 10.1097/01.mlg.0000231786.10969.3f.
The objective of this study was to determine if endoscopic sinus surgery (ESS) is effective in the management of chronic recurrent rhinosinusitis (CRRS).
A consecutive series of patients with CRRS diagnosed according to stringent criteria was prospectively examined before and at least 1 year after ESS. Paranasal sinus computed tomography scans were staged and ESS was performed targeting radiographic disease and the ostiomeatal complex. Preoperative and postoperative disease severities in terms of symptom scores, medicine utilization, and resource factors were assessed using the rhinosinusitis symptom inventory (RSI). Improvements in RSI symptom domains, medical and economic resource factors were determined using effect sizes and statistical comparison before and after ESS.
Nineteen patients (mean age, 42.3 years) completed the study with a mean follow up of 19.1 months. The mean Lund score was 3.42 (standard deviation, 4.09). Statistically significant decreases in nasal (-36.1), facial (-28.4), oropharyngeal (-34.6), systemic (-24.7), and total (-31.9) RSI symptom domain scores were observed (all P < .003) with effect sizes ranging from 0.87 to 1.63 (strong surgical effect). Statistically significant decreases in antihistamine use (-30%, P = .031), number of workdays missed as a result of CRRS (-1.9, P = .035), and number of acute infectious episodes (-2.5, P = .006) were also observed. However, declines in weeks of antibiotic use (-2.8 weeks, P = .293) and number of antibiotic courses (-1.7, P = .118) were not significant.
Patients with CRRS may substantially benefit both symptomatically and medically from ESS. Although surgery should be used cautiously in treating CRRS, further trials of ESS for CRRS are warranted.
本研究的目的是确定鼻内镜鼻窦手术(ESS)在慢性复发性鼻-鼻窦炎(CRRS)的治疗中是否有效。
根据严格标准诊断为CRRS的一系列连续患者在ESS术前及术后至少1年进行前瞻性检查。对鼻窦计算机断层扫描进行分期,并针对影像学疾病和窦口鼻道复合体进行ESS。使用鼻窦炎症状量表(RSI)评估术前和术后在症状评分、药物使用及资源因素方面的疾病严重程度。通过计算效应量并比较ESS前后的数据,确定RSI症状领域、医疗和经济资源因素的改善情况。
19例患者(平均年龄42.3岁)完成了本研究,平均随访时间为19.1个月。平均Lund评分为3.42(标准差4.09)。观察到鼻(-36.1)、面部(-28.4)、口咽(-34.6)、全身(-24.7)及总(-31.9)RSI症状领域评分有统计学意义的下降(均P < .003),效应量范围为0.87至1.63(强大的手术效果)。还观察到抗组胺药使用量有统计学意义的下降(-30%,P = .031)、因CRRS导致的误工天数减少(-1.9,P = .035)以及急性感染发作次数减少(-2.5,P = .006)。然而,抗生素使用周数的下降(-2.8周,P = .293)和抗生素疗程数的下降(-1.7,P = .118)并不显著。
CRRS患者可能在症状和医学方面从ESS中大幅获益。尽管在治疗CRRS时应谨慎使用手术,但ESS用于CRRS的进一步试验是有必要的。