van Ruth Serge, Jansman Frank G A, Sanders Cornelis J
Department of Dermatology and Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Pharm World Sci. 2006 Jun;28(3):159-62. doi: 10.1007/s11096-006-9030-x. Epub 2006 Sep 27.
Topical 5-fluorouracil 5% cream is one of the treatment modalities for non-melanoma skin cancer (NMSC). There is a lack of suitable therapies to treat patients with extensive NMSC. In this paper we report two patients with extensive NMSC treated by total body application of topical 5-fluorouracil 5% cream.
Topical 5-fluorouracil 5% cream was applied twice daily to the total body, including normal appearing skin. During the treatment, weekly blood samples were taken for measurement of 5-fluorouracil levels. All samples showed a 5-fluorouracil level less than the detection level of 10 microg/l. Total body 5- fluorouracil 5% cream was shown to be an effective treatment in our patients; the majority of lesions cleared in both patients.
In conclusion, total body topical 5- fluorouracil 5% cream application was successful in two patients with extensive NMSC. No detectable serum level of 5-fluorouracil could be determined. Pain and secondary infections were important side effects in our patients. However, in patients with extensive NMSC this treatment may be considered.
5%氟尿嘧啶外用乳膏是治疗非黑色素瘤皮肤癌（NMSC）的方法之一。目前缺乏适用于治疗广泛性NMSC患者的疗法。在本文中，我们报告了两名广泛性NMSC患者，通过全身涂抹5%氟尿嘧啶外用乳膏进行治疗。
5%氟尿嘧啶外用乳膏每天全身涂抹两次，包括外观正常的皮肤。治疗期间，每周采集血样以检测氟尿嘧啶水平。所有样本显示氟尿嘧啶水平低于10微克/升的检测水平。全身涂抹5%氟尿嘧啶外用乳膏对我们的患者显示出有效治疗效果；两名患者的大多数皮损均已消退。
总之，全身外用5%氟尿嘧啶乳膏治疗两名广泛性NMSC患者取得成功。未检测到血清氟尿嘧啶水平。疼痛和继发感染是我们患者的重要副作用。然而，对于广泛性NMSC患者，可考虑采用这种治疗方法。
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