Han Sandra Y, Youker Summer
Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
J Drugs Dermatol. 2011 Oct;10(10):1201-3.
Topical fluorouracil is widely used for the treatment of precancerous and cancerous lesions of the skin. The most common side effect of this medication is localized irritant dermatitis. The authors report a case of dysgeusia with metallic taste as a side effect of this medication. While not previously seen with topical use, this is not an uncommon side effect seen with systemic administration of 5-fluorouracil. The etiology of dysgeusia from chemotherapeutic agents and systemic absorption of fluorouracil is discussed.
局部用氟尿嘧啶广泛用于治疗皮肤癌前病变和癌性病变。这种药物最常见的副作用是局部刺激性皮炎。作者报告了1例以金属味味觉障碍为该药物副作用的病例。虽然局部使用时以前未见此情况，但这在5-氟尿嘧啶全身给药时是一种常见的副作用。本文讨论了化疗药物引起味觉障碍以及氟尿嘧啶全身吸收的病因。
