青光眼、糖尿病性和葡萄膜炎性眼病患者房水中转化生长因子-β水平
Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes.
作者信息
Min Seong Hee, Lee Tong-Il, Chung Yun Seok, Kim Hwang Ki
机构信息
Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.
出版信息
Korean J Ophthalmol. 2006 Sep;20(3):162-5. doi: 10.3341/kjo.2006.20.3.162.
PURPOSE
Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma.
METHODS
The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.
RESULTS
The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG.
CONCLUSIONS
These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.
目的
已知转化生长因子-β2在原发性开角型青光眼（POAG）和糖尿病患者的房水中水平升高，但在葡萄膜炎相关性继发性青光眼中则不然。我们研究了不同类型青光眼患者房水中总转化生长因子-β2水平和活性形式的转化生长因子-β2水平。
方法
采用双抗体“夹心-间接”ELISA法，检测63例原发性开角型青光眼、糖尿病性新生血管性青光眼（NVG）和葡萄膜炎相关性继发性开角型青光眼（SOAG）患者房水中总转化生长因子-β2和活性形式的转化生长因子-β2的浓度。
结果
POAG、NVG和SOAG房水样本中总转化生长因子-β2水平升高。POAG和NVG房水样本中活性转化生长因子-β2水平也升高，而SOAG房水样本中活性转化生长因子-β2水平在正常范围内。
结论
这些结果表明，转化生长因子-β2水平可能在各种类型青光眼的病理过程中起作用。
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