益维宁与孕三烯酮对Ⅲ期子宫内膜异位症术后治疗效果的对比研究
Comparative study on the efficacy of Yiweining and Gestrinone for post-operational treatment of stage III endometriosis.
作者信息
Yang Dong-xia, Ma Wen-guang, Qu Fan, Ma Bao-zhang
机构信息
Department of Gynecology, Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
出版信息
Chin J Integr Med. 2006 Sep;12(3):218-20. doi: 10.1007/BF02836527.
OBJECTIVE
To observe the clinical efficacy and safety of Yiweining (YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).
METHODS
Fifty-two patients of EM-III after operation were randomly assigned into three groups, the YWN group (20 patients) was treated through oral intake of YWN 200 ml, twice a day; the GT group (19 patients) treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6 - 30 months after the end of the medication.
RESULTS
The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group (30.7%, P < 0.05). Besides, the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%, P < 0.05).
CONCLUSION
Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT.
目的
观察益维宁（YWN）与孕三烯酮（GT）治疗Ⅲ期子宫内膜异位症（EM-Ⅲ）术后患者的临床疗效及安全性。
方法
将52例EM-Ⅲ术后患者随机分为三组，YWN组（20例）口服益维宁200 ml，每日2次；GT组（19例）服用孕三烯酮2.5 mg，每周2次，于术后第7天开始用药，持续6个月。对照组（13例）未接受治疗。6个月为1个疗程，停药后6 - 30个月进行随访研究。
结果
YWN组和GT组的复发率分别为5.0%和5.3%，两组间差异无统计学意义，但均低于对照组（30.7%，P < 0.05）。此外，YWN组的不良反应发生率低于GT组（10.0%比31.6%，P < 0.05）。
结论
应用益维宁预防子宫内膜异位症术后复发有效、安全，其疗效与孕三烯酮相似。
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