Jan L Y, Jan Y N
Howard Hughes Medical Institute, University of California, San Francisco 94143.
Trends Neurosci. 1990 Oct;13(10):415-9. doi: 10.1016/0166-2236(90)90123-r.
Potassium channels are a diverse group of ion channels present in most eukaryotic cells that have been examined. Over 30 different potassium channels have been characterized biophysically. They show different sensitivities to voltage and/or intracellular messengers, and have different kinetic or pharmacological properties. The wide range of potassium channel properties reflects the broad spectrum of cellular functions that they serve, including control of synaptic efficacy, of heart beat, and of endocrine and exocrine secretion. How might this tremendous diversity of potassium channels be generated? Partial answers have begun to emerge as molecular studies of potassium channel genes have become possible over the past few years.
钾通道是一类多样的离子通道，存在于大多数已被研究的真核细胞中。超过30种不同的钾通道已通过生物物理学方法得以表征。它们对电压和/或细胞内信使表现出不同的敏感性，并且具有不同的动力学或药理学特性。钾通道特性的广泛差异反映了它们所服务的细胞功能的广泛范围，包括对突触效能、心跳以及内分泌和外分泌分泌的控制。钾通道如此巨大的多样性是如何产生的呢？在过去几年中，随着对钾通道基因的分子研究成为可能，部分答案已开始浮现。
