Jiang Meisheng, Bajpayee Neil S
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Neurosignals. 2009;17(1):23-41. doi: 10.1159/000186688. Epub 2009 Feb 12.
Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.
Go是中枢神经系统中含量最丰富的G蛋白，在哺乳动物大脑中约占膜蛋白的1%。它的功能是将细胞表面受体与细胞内效应器偶联，这是细胞接收、解读和响应细胞外信号的关键过程。Go蛋白属于对百日咳毒素敏感的G蛋白Gi/Go亚家族。许多G蛋白偶联受体通过Go将刺激传递给细胞内效应器。Go调节多种细胞效应器，包括离子通道、酶，甚至小GTP酶，以调节细胞功能。本综述总结了Go研究的一些进展，并提出了在探索Go的功能作用时有待进一步探讨的领域。
