du Plessis Irné, Mitchell Duncan, Niesler Carola, Laburn Helen P
Brain Function Research Unit, School of Physiology, University of the Witwatersrand Medical School of Physiology, 7 York Road, Parktown 2193, South Africa.
Brain Res. 2006 Nov 20;1120(1):124-30. doi: 10.1016/j.brainres.2006.08.062. Epub 2006 Sep 26.
We determined c-Fos immunoreactivity (Fos-IR) in selected hypothalamic nuclei, the organum vasculosum of the laminae terminals (OVLT) and somatosensory cortex of rats after hyperthermia induced by exogenous heat exposure, Gram-negative or Gram-positive pyrogen administration. The magnitude of Fos-IR was similar in thermoregulatory hypothalamic nuclei of rats after heat exposure or lipopolysaccharide (LPS) injection, despite the different origins of the hyperthermias. Heat-induced hyperthermia was associated with increased Fos-IR in the somatosensory cortex. LPS, but not heat exposure or injection of killed Staphylococcus aureus cells activated OVLT neurons. The OVLT may thus not be a port of entry for humoral mediators of Gram-positive bacterial fevers.
我们测定了经外源热暴露、革兰氏阴性或革兰氏阳性致热原给药诱导大鼠体温过高后，其特定下丘脑核团、终板血管器（OVLT）及体感皮层中的c-Fos免疫反应性（Fos-IR）。尽管体温过高的来源不同，但热暴露或注射脂多糖（LPS）后，大鼠体温调节下丘脑核团中的Fos-IR强度相似。热诱导的体温过高与体感皮层中Fos-IR增加有关。LPS激活了OVLT神经元，但热暴露或注射灭活的金黄色葡萄球菌细胞未激活该神经元。因此，OVLT可能不是革兰氏阳性菌热体液介质的进入端口。
