足月胎盘伴母婴转移的胎盘内绒毛膜癌：一例报告并文献复习
Intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases: a case report and review of the literature.
作者信息
Liu Jianping, Guo Lina
机构信息
Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.
出版信息
Gynecol Oncol. 2006 Dec;103(3):1147-51. doi: 10.1016/j.ygyno.2006.08.007. Epub 2006 Sep 26.
BACKGROUND
Intraplacental choriocarcinoma is rare, and usually results in maternal metastasis at the time of diagnosis. Intraplacental choriocarcinoma involves both mother and infant is extremely rare. There was only one case report of intraplacental choriocarcinoma with confirmed metastases involving both the mother and the infant.
CASE
We describe a second case of intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases. Grossly, the primary lesion of the placenta resembled an old infarct. Microscopically, clusters of malignant trophoblasts arose from residual normal chorionic villi and infiltrated into the intervillous spaces. Both the mother and the infant received chemotherapy and were alive without disease after one year's follow-up.
CONCLUSION
The optimal treatment for intraplacental choriocarcinoma is controversial. However, aggressive chemotherapy is suggested for patients with metastatic disease.
背景
胎盘内绒毛膜癌罕见，通常在诊断时已发生母体转移。胎盘内绒毛膜癌累及母婴极为罕见。仅有一例胎盘内绒毛膜癌确诊转移累及母婴的病例报告。
病例
我们描述了第二例足月胎盘发生的胎盘内绒毛膜癌，伴有母婴转移。大体上，胎盘的原发病变类似陈旧性梗死。显微镜下，恶性滋养层细胞簇从残留的正常绒毛膜绒毛中长出并浸润至绒毛间隙。母婴均接受了化疗，随访一年后均存活且无疾病复发。
结论
胎盘内绒毛膜癌的最佳治疗方法存在争议。然而，对于有转移疾病的患者建议积极化疗。
Zotero 插件