Dana A, Saldanha G J, Doshi R, Rustin G J
Department of Medical Oncology, Charing Cross Hospital, London, United Kingdom.
Gynecol Oncol. 1996 Apr;61(1):147-9. doi: 10.1006/gyno.1996.0114.
Gestational choriocarcinoma associated with a viable pregnancy is extremely rare, and such choriocarcinoma with metastases presenting during the pregnancy is even more exceptional. Metastases from this tumor may present in a variety of ways depending on the site of the metastatic lesion, and can be fatal before choriocarcinoma is even suspected. We describe a 32-year-old primigravida presenting at 31 weeks gestation with a grand mal seizure due to cerebral metastases secondary to gestational choriocarcinoma who was subsequently successfully treated with chemotherapy. To our knowledge this is the first reported case of choriocarcinoma presenting with signs due to cerebral metastases during pregnancy where both the mother and child survived. This paper emphasizes the need to consider metastatic choriocarcinoma in any gravid female who presents with unusual neurological signs because of the life-threatening nature of this potentially curable disease.
与存活妊娠相关的妊娠滋养细胞肿瘤极为罕见，而在孕期出现转移的此类绒毛膜癌更是罕见。该肿瘤的转移可能因转移病灶的部位不同而有多种表现方式，甚至在怀疑患有绒毛膜癌之前就可能致命。我们报告一例32岁初产妇，孕31周时因妊娠滋养细胞肿瘤脑转移导致癫痫大发作，随后经化疗成功治疗。据我们所知，这是首例报道的孕期因脑转移出现症状且母婴均存活的绒毛膜癌病例。本文强调，鉴于这种潜在可治愈疾病的危及生命性，对于任何出现异常神经症状的妊娠女性，都有必要考虑转移性绒毛膜癌。
