Pontes J E, Jabalameli P, Montie J, Foemmel R, Howard P D, Boyett J
Department of Urology, Cleveland Clinic Foundation, Ohio.
Urology. 1990 Nov;36(5):415-9. doi: 10.1016/s0090-4295(90)80287-w.
Six patients with localized prostatic carcinoma undergoing radical prostatectomy were studied by serial sample collection from the time of surgical removal of the prostate up to one week in the postoperative period. Of the three markers studied (PAP, PSA, LASA), half-life of specific prostatic markers were calculated. Half-life of PAP was found to be 7.25 hours +/- SE of 0.7 hours. For PSA the half-life could be obtained in 4 of 6 patients and was found to be 45.5 hours +/- SE 4.9 hours. In 2 patients PSA did not fall in a regular fashion and half-life could not be obtained. In both patients metastatic disease has developed within six months of surgery. LASA demonstrated progressive increase following surgery, most likely due to associated inflammatory reaction. These studies confirm previous observations that PSA is a more sensitive marker than PAP, and that the presence of an elevated PSA after radical prostatectomy denotes the presence of residual disease.
对6例接受根治性前列腺切除术的局限性前列腺癌患者进行了研究，从前列腺手术切除时开始，直至术后一周进行系列样本采集。在所研究的三种标志物（前列腺酸性磷酸酶（PAP）、前列腺特异抗原（PSA）、亮氨酸氨基肽酶（LASA））中，计算了特异性前列腺标志物的半衰期。发现PAP的半衰期为7.25小时，标准误为0.7小时。对于PSA，6例患者中有4例可得出半衰期，发现为45.5小时，标准误为4.9小时。2例患者的PSA未呈规律下降，无法得出半衰期。这2例患者均在手术后6个月内发生了转移性疾病。LASA在术后呈进行性升高，很可能是由于相关的炎症反应。这些研究证实了之前的观察结果，即PSA是比PAP更敏感的标志物，并且根治性前列腺切除术后PSA升高表明存在残留疾病。
