Huang David B, Mohanty Alakananda, DuPont Herbert L, Okhuysen Pablo C, Chiang Tom
Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, 535EE, Houston, TX 77030, USA.
University of Texas at Houston School of Public Health, 1200 Herman Pressler - E50, Houston, TX 77030, USA.
J Med Microbiol. 2006 Oct;55(Pt 10):1303-1311. doi: 10.1099/jmm.0.46674-0.
Enteroaggregative Escherichia coli (EAEC) is an increasingly recognized enteric pathogen. It is a cause of both acute and persistent diarrhoea among children, adults and HIV-infected persons, in both developing and developed countries. In challenge studies, EAEC has caused diarrhoeal illness with the ingestion of 10(10) c.f.u. Outbreaks of diarrhoeal illness due to EAEC have been reported, and linked to the ingestion of contaminated food. Diarrhoeal illness due to EAEC is the result of a complex pathogen-host interaction. Some infections due to EAEC result in diarrhoeal illness and elicit an inflammatory response, whereas other infections do not result in a symptomatic infection. Many putative virulence genes and EAEC strains that produce biofilm have been identified; however, the clinical significance of these genes and of biofilm production has yet to be defined. A -251 AA single nucleotide polymorphism (SNP) in the interleukin (IL)-8 promoter region is reported to increase host susceptibility to EAEC diarrhoea. Ciprofloxacin and rifaximin continue to be an effective treatment in persons infected with EAEC. This review is intended to provide an updated review for healthcare workers on EAEC, an emerging enteric pathogen.
肠集聚性大肠杆菌（EAEC）是一种日益受到关注的肠道病原体。在发达国家和发展中国家，它都是儿童、成人及HIV感染者急性和持续性腹泻的病因。在感染性研究中，摄入10(10) c.f.u.的EAEC可引发腹泻病。已有因EAEC导致腹泻病暴发的报道，且与摄入受污染食物有关。EAEC所致腹泻病是病原体与宿主复杂相互作用的结果。一些由EAEC引起的感染会导致腹泻病并引发炎症反应，而其他感染则不会导致有症状的感染。已鉴定出许多假定的毒力基因和产生生物膜的EAEC菌株；然而，这些基因及生物膜产生的临床意义尚未明确。据报道，白细胞介素（IL）-8启动子区域的一个-251 AA单核苷酸多态性（SNP）会增加宿主对EAEC腹泻的易感性。环丙沙星和利福昔明仍是治疗EAEC感染患者的有效药物。本综述旨在为医护人员提供关于EAEC这一新兴肠道病原体的最新综述。
