Buck Jessica M, Lexau Catherine, Shapiro Miriam, Glennen Anita, Boxrud David J, Koziol Bonnie, Whitney Cynthia G, Beall Bernard, Danila Richard, Lynfield Ruth
Acute Disease Investigation and Control Section, Minnesota Department of Health, St. Paul, MN 55164-0975, USA.
Pediatr Infect Dis J. 2006 Oct;25(10):906-11. doi: 10.1097/01.inf.0000238143.96607.ec.
The Minnesota Department of Health (MDH) was notified of an outbreak of conjunctivitis in city A with cultures positive for Streptococcus pneumoniae.
MDH staff contacted clinics and schools in city A and city B regarding conjunctivitis cases, reviewed clinical findings of conjunctivitis cases in city A and collected isolates for subtyping.
Between September 1 and December 12, 2003, cities A and B reported 735 conjunctivitis cases. Fifty-one percent of the cases were reported from schools, childcare centers and colleges. Adults were more likely to report itching, burning or swelling of the eye(s); children were more likely to report crusty eyes (P < 0.05). Forty-nine percent of conjunctival cultures (71 of 144) were positive for S. pneumoniae. All isolates were nontypeable by serotyping. Pulsed field gel electrophoresis identified 3 clonal groups with 84% of isolates belonging to one clonal group. Multilocus sequence typing revealed that isolates had the same multilocus sequence type as isolates from a 2002 outbreak at a New England college.
This outbreak was widespread in the community and conjunctivitis clinical presentation varied by age. The predominant strains in this outbreak were related to a pneumococcal strain implicated in prior conjunctivitis outbreaks, suggesting these strains have a predilection for causing conjunctivitis.
明尼苏达州卫生部（MDH）接到通知，A市爆发了结膜炎，培养结果显示肺炎链球菌呈阳性。
MDH工作人员就结膜炎病例与A市和B市的诊所及学校取得联系，审查了A市结膜炎病例的临床检查结果，并收集了分离株进行亚型分析。
在2003年9月1日至12月12日期间，A市和B市共报告了735例结膜炎病例。其中51%的病例来自学校、日托中心和学院。成年人更有可能报告眼睛瘙痒、灼痛或肿胀；儿童更有可能报告眼睛有结痂（P<0.05）。49%的结膜培养物（144份中的71份）肺炎链球菌呈阳性。所有分离株通过血清分型均无法分型。脉冲场凝胶电泳确定了3个克隆群，84%的分离株属于其中一个克隆群。多位点序列分型显示，这些分离株与新英格兰一所学院2002年爆发疫情时的分离株具有相同的多位点序列类型。
此次疫情在社区中广泛传播，结膜炎的临床表现因年龄而异。此次疫情中的主要菌株与先前结膜炎疫情中涉及的肺炎球菌菌株有关，表明这些菌株易引发结膜炎。
