Freychet L, Duboc D, Guérin F, Chomette G
Service de cardiologie, hôpital Cochin, Paris.
Arch Mal Coeur Vaiss. 1990 Oct;83(11):1729-32.
The authors report the case of a 61 year-old patient treated by tetracycline for very probable Whipple's disease who developed constrictive pericarditis requiring pericardectomy. Although intestinal biopsy was negative, histological examination of the resected pericardium was very suggestive of a cardiac localisation of Whipple's disease, showing a fibrous pericarditis with a mononuclear infiltration including PAS-positive histiocytes. In addition, the same histological changes were found in a small fragment of myocardial biopsy. This case illustrates the prevalence and consequences of cardiac involvement in Whipple's disease.
作者报告了一例61岁患者的病例，该患者因极有可能患惠普尔病而接受四环素治疗，随后发展为缩窄性心包炎，需要进行心包切除术。尽管肠道活检结果为阴性，但切除的心包的组织学检查强烈提示惠普尔病累及心脏，表现为纤维性心包炎伴单核细胞浸润，包括PAS阳性组织细胞。此外，在心肌活检的一小片组织中也发现了相同的组织学变化。该病例说明了惠普尔病中心脏受累的普遍性及其后果。
