溴苯酰溴，一种磷脂酶A2抑制剂，可减轻大鼠化学诱导的胃十二指肠溃疡。
Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats.
作者信息
Tariq Mohammad, Elfaki Ibrahim, Khan Haseeb-Ahmad, Arshaduddin Mohammad, Sobki Samia, Al Moutaery Meshal
机构信息
Frcpath, Frsc Senior Consultant and Director of Research, Armed Forces Hospital, Po Box 7897 (W-912), Riyadh 11159, Kingdom of Saudi Arabia.
出版信息
World J Gastroenterol. 2006 Sep 28;12(36):5798-804. doi: 10.3748/wjg.v12.i36.5798.
AIM
To study the effect of bromophenacyl bromide (BPB), a phospholipase A2 inhibitor on gastric secretion and to protect chemically induced gastric and duodenal ulcers in rats.
METHODS
Acid secretion studies were undertaken in pylorus-ligated rats with BPB treatment (0, 5, 15 and 45 mg/kg). Gastric and duodenal lesions in the rats were induced by ethanol and cysteamine respectively. The levels of gastric wall mucus, nonprotein sulfhydryls (NP-SH) and myeloperoxidase (MPO) were also measured in the glandular stomach of rats following ethanol induced gastric lesions.
RESULTS
BPB produced a dose-dependent inhibition of gastric acid secretion and acidity in rats. Pretreatment with BPB significantly attenuated the formation of ethanol induced gastric lesion. BPB also protected intestinal mucosa against cysteamine-induced duodenal ulcers. The antiulcer activity of BPB was associated with significant inhibition of ethanol-induced depletion of gastric wall mucus, NP-SH and MPO. These findings pointed towards the mediation of sulfhydryls in BPB induced gastrointestinal cytoprotection.
CONCLUSION
BPB possesses significant antiulcer and cytoprotective activity against experimentally induced gastroduodenal lesions.
目的
研究磷脂酶A2抑制剂溴苯酰溴（BPB）对大鼠胃分泌的影响，并保护大鼠化学诱导的胃和十二指肠溃疡。
方法
对幽门结扎的大鼠进行酸分泌研究，给予BPB处理（0、5、15和45mg/kg）。大鼠的胃和十二指肠损伤分别由乙醇和半胱胺诱导。在乙醇诱导胃损伤后，还测定了大鼠腺胃中胃壁黏液、非蛋白巯基（NP-SH）和髓过氧化物酶（MPO）的水平。
结果
BPB对大鼠胃酸分泌和酸度产生剂量依赖性抑制。BPB预处理显著减轻了乙醇诱导的胃损伤的形成。BPB还保护肠黏膜免受半胱胺诱导的十二指肠溃疡。BPB的抗溃疡活性与显著抑制乙醇诱导的胃壁黏液、NP-SH和MPO的消耗有关。这些发现表明巯基在BPB诱导的胃肠道细胞保护中起介导作用。
结论
BPB对实验诱导的胃十二指肠损伤具有显著的抗溃疡和细胞保护活性。
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