Tariq M, Al Moutaery A R
Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia.
Res Commun Mol Pathol Pharmacol. 1997 Aug;97(2):185-98.
Glycine, a neutral amino acid has been studied for its ability to inhibit gastric secretion and to protect the gastric mucosa against chemically and stress-induced ulcers. Acid secretion studies were undertaken in pylorus-ligated rats with and without glycine treatment. Experimental gastric lesions were induced by hypothermic-restraint stress, indomethacin and necrotizing agents including 80% ethanol, 0.2 M sodium hydroxide and 0.6 M hydrochloric acid in rats. The level of nonprotein sulfhydryl compounds and gastric wall mucus were also measured in the glandular stomach of the rats following ethanol-induced gastric lesions. The results of this study demonstrate that glycine dose dependently reduced the gastric secretions in rats. Pretreatment with glycine significantly protected animals against stress-, indomethacin- and necrotizing agents induced gastric lesions. The antiulcer activity of glycine was associated with significant inhibition of ethanol-induced depletion of nonprotein sulfhydryls and gastric wall mucus. In conclusion, this study demonstrates that glycine possesses significant antiulcer and cytoprotective activity. However, further detailed studies are warranted to establish the mechanism(s) of action, and to determine its role in the prophylaxis and treatment of gastric ulcer disease.
甘氨酸是一种中性氨基酸，人们对其抑制胃酸分泌以及保护胃黏膜免受化学物质和应激诱导性溃疡影响的能力进行了研究。在幽门结扎的大鼠中进行了有无甘氨酸处理情况下的胃酸分泌研究。通过低温束缚应激、吲哚美辛以及包括80%乙醇、0.2M氢氧化钠和0.6M盐酸在内的坏死剂在大鼠中诱导实验性胃损伤。在乙醇诱导胃损伤后的大鼠腺胃中还测定了非蛋白巯基化合物水平和胃壁黏液。本研究结果表明，甘氨酸可剂量依赖性地减少大鼠胃酸分泌。甘氨酸预处理可显著保护动物免受应激、吲哚美辛和坏死剂诱导的胃损伤。甘氨酸的抗溃疡活性与对乙醇诱导的非蛋白巯基和胃壁黏液耗竭的显著抑制有关。总之，本研究表明甘氨酸具有显著的抗溃疡和细胞保护活性。然而，需要进一步进行详细研究以确定其作用机制，并确定其在胃溃疡疾病预防和治疗中的作用。
