[Concentration of interleukin 6 and 10 in tick-borne and purulend encephalomeningitis].

UNLABELLED

The aim of the study was to evaluate concentrations of interleukin 6 (IL-6) and interleukin (IL-10) in serum and cerebrospinal fluid (csf) of patients with tick-borne encephalitis (tbe) and purulent meningitis before and after 4 weeks of treatment.

MATERIAL AND METHODS

Group I consisted of 23 patients with tbe and group II - 16 patients with bacterial meningitis. Group III (control) consisted of 10 healthy men.

RESULTS AND CONCLUSIONS

In patients with tbe and purulent meningitis concentrations of IL-6 and IL-10 in serum and csf were initially increased and tended to remain increased after 4 weeks of treatment. It suggests significant role of IL-6 and IL-10 in inflammatory process within cns. Higher concentrations of IL-6 than IL-10 in csf than in serum suggests their local synthesis within cns and tendency to the limitation of the inflammatory response to the intratecal compartment. Concentrations of both IL-6 and IL-10 in csf and serum remained sgnificantly higher in patints with purulent meningits than in tbe, both before and after treatment. This observation may be helpful in diagnosing the ethiology of meningitis and meningoencephalitis and monitoring the course of the disease.