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用于干细胞研究的卵子采集:医学风险与伦理问题

Egg harvesting for stem cell research: medical risks and ethical problems.

作者信息

Beeson Diane, Lippman Abby

机构信息

Department of Sociology and Social Services, California State University, East Bay, Hayward, CA 94542, USA.

出版信息

Reprod Biomed Online. 2006 Oct;13(4):573-9. doi: 10.1016/s1472-6483(10)60647-5.

DOI:10.1016/s1472-6483(10)60647-5
PMID:17007682
Abstract

Increasingly, researchers are seeking eggs from young women to be used for embryo cloning procedures. The harvesting of multiple eggs often involves the administration of drugs that have not been approved for this purpose. Also these drugs have not been adequately studied for their long-term effects on women despite research providing some evidence of significant harm to women in both the short and long term. Current practices follow a historical pattern of exposing women to risks that ultimately prove unacceptable. In addition, egg harvesting is taking place in a research climate marked by conflicts of interest, the misleading use of language to describe research goals, and a commercial push that may lead to the exploitation of young women. In this article, we outline these matters and explain how they are leading to an international campaign for a moratorium on egg harvesting for cloning purposes.

摘要

越来越多的研究人员正在寻求年轻女性的卵子用于胚胎克隆程序。采集多个卵子通常涉及使用未经批准用于此目的的药物。而且,尽管研究提供了一些证据表明这些药物对女性短期和长期都有重大危害,但它们对女性的长期影响尚未得到充分研究。当前的做法遵循了一种历史模式,即让女性面临最终被证明不可接受的风险。此外,卵子采集是在一个存在利益冲突、对研究目标进行误导性语言描述以及商业推动可能导致对年轻女性剥削的研究环境中进行的。在本文中,我们概述了这些问题,并解释了它们是如何引发一场国际运动,要求暂停用于克隆目的的卵子采集的。

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1
Egg harvesting for stem cell research: medical risks and ethical problems.用于干细胞研究的卵子采集:医学风险与伦理问题
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The commercialization of human eggs in mitochondrial replacement research.线粒体替代研究中人类卵子的商业化。
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Research ethics. South Korean cloning team denies improprieties.研究伦理。韩国克隆团队否认不当行为。
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For love or money? The saga of Korean women who provided eggs for embryonic stem cell research.为了爱还是为了钱?提供卵子用于胚胎干细胞研究的韩国女性的传奇故事。
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引用本文的文献

1
Alignment between expectations and experiences of egg donors: what does it mean to be informed?卵子捐赠者的期望与经历之间的一致性:充分知情意味着什么?
Reprod Biomed Soc Online. 2020 Sep 19;12:1-13. doi: 10.1016/j.rbms.2020.08.003. eCollection 2021 Mar.
2
Knowledge and Attitude about Stem Cells and Their Application in Medicine among Nursing Students in Universiti Sains Malaysia, Malaysia.马来西亚理科大学护理专业学生对干细胞及其在医学中应用的知识和态度
Malays J Med Sci. 2015 Jul-Aug;22(4):23-31.
3
Egg donation brokers: an analysis of agency versus in vitro fertilization clinic websites.
卵子捐赠中介:对中介机构与体外受精诊所网站的分析
J Reprod Med. 2014 Nov-Dec;59(11-12):534-41.
4
From embryonic stem cells to iPS - an ethical perspective.从胚胎干细胞到诱导多能干细胞——伦理视角
Cell Prolif. 2011 Apr;44 Suppl 1(Suppl 1):70-84. doi: 10.1111/j.1365-2184.2010.00723.x.
5
Oversight framework over oocyte procurement for somatic cell nuclear transfer: comparative analysis of the Hwang Woo Suk case under South Korean bioethics law and U.S. guidelines for human embryonic stem cell research.体细胞核移植卵母细胞获取监管框架:韩国生物伦理法与美国人类胚胎干细胞研究指南下黄禹锡案的比较分析。
Theor Med Bioeth. 2009;30(5):367-84. doi: 10.1007/s11017-009-9113-5. Epub 2009 Aug 4.
6
Payment of egg donors in stem cell research in the USA.美国干细胞研究中卵子捐赠者的报酬问题。
Reprod Biomed Online. 2009 May;18(5):603-8. doi: 10.1016/s1472-6483(10)60002-8.
7
The stem cell debate continues: the buying and selling of eggs for research.干细胞争论仍在继续:用于研究的卵子买卖。
J Med Ethics. 2007 Dec;33(12):726-31. doi: 10.1136/jme.2007.022129.