德国人群中的同型半胱氨酸与颈动脉内膜中层厚度：缺乏临床相关性。
Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevance.
作者信息
Linnebank Michael, Moskau Susanna, Farmand Susan, Fliessbach Klaus, Kölsch Heike, Bös Monika, Grothe Christoph, Becker Dietmar, Harbrecht Ursula, Pohl Christoph, Wüllner Ullrich, Klockgether Thomas
机构信息
Department of Neurology, University Hospital Bonn, Bonn, Germany.
出版信息
Stroke. 2006 Nov;37(11):2840-2. doi: 10.1161/01.STR.0000244764.02851.d3. Epub 2006 Sep 28.
BACKGROUND AND PURPOSE
Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT.
METHODS
We analyzed the association of personal, clinical, and biochemical data (multivariate analysis) and of 9 polymorphisms involved in Hcys metabolism (ANOVA) with CCA IMT in 714 individuals of 187 families.
RESULTS
CCA IMT was significantly predicted by age, sex, creatinine levels, lipoprotein(a) levels, pack-years of smoking, the presence of hypertension, and the presence of diabetes mellitus but not by Hcys levels. Homozygosity for the T allele of the polymorphism methylenetetrahydrofolate reductase c.677C>T was significantly associated with higher Hcys levels but not with a higher CCA IMT.
CONCLUSIONS
These data do not support the thesis that elevated Hcys levels are causally involved in cerebrovascular disease.
背景与目的
颈总动脉内膜中层厚度（CCA IMT）是中风的一个预测指标。本研究旨在分析同型半胱氨酸（Hcys）代谢是否会影响CCA IMT。
方法
我们在187个家庭的714名个体中，分析了个人、临床和生化数据（多变量分析）以及9种参与Hcys代谢的多态性（方差分析）与CCA IMT之间的关联。
结果
CCA IMT可通过年龄、性别、肌酐水平、脂蛋白(a)水平、吸烟包年数、高血压的存在以及糖尿病的存在进行显著预测，但不能通过Hcys水平进行预测。亚甲基四氢叶酸还原酶c.677C>T多态性的T等位基因纯合性与较高的Hcys水平显著相关，但与较高的CCA IMT无关。
结论
这些数据不支持Hcys水平升高与脑血管疾病存在因果关系这一论点。
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