1st Department of Neurology, Faculty of Medicine, Comenius University, Mickiewiczova 13, 813 69, Bratislava, Slovakia.
AB Neuro, Jilemnickeho 547/10, 911 01, Trencin, Slovakia.
BMC Res Notes. 2022 Sep 5;15(1):284. doi: 10.1186/s13104-022-06176-z.
There are conflicting data regarding the relationship between Parkinson's disease (PD) and the atherosclerotic process. This study aimed to compare endothelial function in patients with PD and matched controls. In PD subjects, we searched for factors contributing to endothelial dysfunction as well. Traditional vascular risk factors, PD characteristics, and PD medication were considered.
We prospectively enrolled 41 patients with PD and 41 controls matched for age, sex, body mass index, and vascular risk factors. Endothelial function (EF) was assessed using peripheral arterial tonometry (EndoPAT 2000 device) and expressed as reperfusion hyperemia index (RHI). Clinical characteristics including PD medication were recorded. RHI was non-significantly lower in the PD group than in controls (1.8 ± 0.5 vs. 1.9 ± 0.5, p = 0.478). In PD patients, in linear regression analysis, smoking (beta = -0.453, p = 0.008) and use of dopamine agonists (beta = -0.365, p = 0.030) were significant contributors in a model predicting RHI. Despite non-significant differences in endothelial dysfunction between PD patients and controls, our results suggest an association between smoking, dopamine agonists, and impaired EF in PD patients. The small sample size, as well as the absence of an extended search for traditional and non-traditional vascular risk factors, are the most important factors limiting the interpretation of the current results.
关于帕金森病（PD）与动脉粥样硬化过程之间的关系，存在相互矛盾的数据。本研究旨在比较 PD 患者和匹配对照者的内皮功能。在 PD 患者中，我们还寻找导致内皮功能障碍的因素。考虑了传统血管危险因素、PD 特征和 PD 药物。
我们前瞻性纳入了 41 名 PD 患者和 41 名匹配的对照者，这些对照者在年龄、性别、体重指数和血管危险因素方面相匹配。使用外周动脉张力测定法（EndoPAT 2000 设备）评估内皮功能，并表示为再灌注充血指数（RHI）。记录了临床特征，包括 PD 药物。PD 组的 RHI 非显著低于对照组（1.8±0.5 对 1.9±0.5，p=0.478）。在 PD 患者中，在线性回归分析中，吸烟（β=-0.453，p=0.008）和使用多巴胺激动剂（β=-0.365，p=0.030）是预测 RHI 的模型中的显著贡献因素。尽管 PD 患者和对照组之间内皮功能障碍无显著差异，但我们的结果表明吸烟、多巴胺激动剂与 PD 患者 EF 受损之间存在关联。样本量小，以及缺乏对传统和非传统血管危险因素的广泛搜索，是限制当前结果解释的最重要因素。
