血清同型半胱氨酸作为急性脑卒中患者颈动脉内膜增厚的危险因素：一项横断面观察性研究。
Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational study.
作者信息
Devasia Anup J, Joy Binu, Tarey Subhash D
机构信息
Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India.
Department of Radiology, St. John's Medical College, Bangalore, Karnataka, India.
出版信息
Ann Indian Acad Neurol. 2016 Jan-Mar;19(1):48-51. doi: 10.4103/0972-2327.168633.
INTRODUCTION
The present study aimed to analyse if there is a correlation between carotid intima medial thickening (CIMT) and Hcy in stroke patients.
METHODOLOGY
We studied 100 consecutive cases of acute anterior circulation strokes at St. John's Medical College, Bangalore, India. Fasting serum samples for homocysteine were sent within 24 hours of admission and all patients underwent a carotid Doppler scan and carotid intima-medial thickness (CIMT) was estimated on both sides.
RESULTS
There was significant correlation between serum homocysteine levels and carotid intima-medial thickness (r = 0.409, p = 0.000). Also after controlling for other possible risk factors it was found that elevations in serum homocysteine levels would cause a variation of 60% in the carotid intima-medial thickening.
CONCLUSION
Serum Hcy levels correlate well with CIMT and hence may predict atherothrombotic events.
引言
本研究旨在分析中风患者的颈动脉内膜中层增厚（CIMT）与同型半胱氨酸（Hcy）之间是否存在相关性。
方法
我们在印度班加罗尔的圣约翰医学院对100例连续的急性前循环中风病例进行了研究。入院后24小时内采集空腹血清样本检测同型半胱氨酸，所有患者均接受颈动脉多普勒扫描，并双侧测量颈动脉内膜中层厚度（CIMT）。
结果
血清同型半胱氨酸水平与颈动脉内膜中层厚度之间存在显著相关性（r = 0.409，p = 0.000）。在控制了其他可能的风险因素后还发现，血清同型半胱氨酸水平升高会导致颈动脉内膜中层增厚出现60%的变化。
结论
血清Hcy水平与CIMT密切相关，因此可能预测动脉粥样硬化血栓形成事件。
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