Rangel Javier, Torabian Sima, Shaikh Ladan, Nosrati Mehdi, Baehner Frederick L, Haqq Chris, Leong Stanley P L, Miller James R, Sagebiel Richard W, Kashani-Sabet Mohammed
Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, University of California San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, USA.
J Clin Oncol. 2006 Oct 1;24(28):4565-9. doi: 10.1200/JCO.2006.07.3833.
To assess the prognostic significance of nuclear receptor coactivator-3 (NCOA3) overexpression in primary cutaneous melanoma.
NCOA3 expression was assessed using immunohistochemical analysis of a melanoma tissue microarray (TMA) containing primary melanomas from 343 patients with defined histology and follow-up. The impact of the presence or absence of various prognostic factors on relapse-free survival (RFS) and disease-specific survival (DSS) of melanoma patients was assessed using Cox regression and Kaplan-Meier analysis. The impact of presence or absence of various factors on sentinel lymph node (SLN) metastasis was assessed using logistic regression analysis.
Increasing degree of NCOA3 expression was significantly predictive of SLN metastasis (P = .013) and the mean number of SLN metastases (P = .031). Kaplan-Meier analysis demonstrated a significant association between NCOA3 overexpression and reduced RFS (P = .021) and DSS (P = .030). Logistic regression analysis revealed increasing degree of NCOA3 expression to be an independent predictor of SLN status (P = .017). Multivariate Cox regression analysis showed the independent impact of NCOA3 expression on RFS (P = .0095) and DSS (P = .021). NCOA3 was the most powerful factor predicting DSS, outperforming tumor thickness and ulceration.
These results identify NCOA3 as a novel, independent marker of melanoma outcome, with a significant impact on SLN metastasis, RFS, and DSS.
评估核受体辅激活因子-3（NCOA3）过表达在原发性皮肤黑色素瘤中的预后意义。
使用免疫组织化学分析法对包含343例具有明确组织学特征和随访信息的原发性黑色素瘤的黑色素瘤组织微阵列（TMA）进行NCOA3表达评估。采用Cox回归和Kaplan-Meier分析评估各种预后因素的有无对黑色素瘤患者无复发生存期（RFS）和疾病特异性生存期（DSS）的影响。采用逻辑回归分析评估各种因素的有无对前哨淋巴结（SLN）转移的影响。
NCOA3表达程度增加可显著预测SLN转移（P = 0.013）和SLN转移的平均数量（P = 0.031）。Kaplan-Meier分析显示NCOA3过表达与降低的RFS（P = 0.021）和DSS（P = 0.030）之间存在显著关联。逻辑回归分析显示NCOA3表达程度增加是SLN状态的独立预测因子（P = 0.017）。多变量Cox回归分析显示NCOA3表达对RFS（P = 0.0095）和DSS（P = 0.021）具有独立影响。NCOA3是预测DSS的最有力因素，优于肿瘤厚度和溃疡情况。
这些结果表明NCOA3是黑色素瘤预后的一种新型独立标志物，对SLN转移、RFS和DSS具有显著影响。
