CAY-1与两性霉素B及伊曲康唑的协同作用。
Synergism of CAY-1 with amphotericin B and itraconazole.
作者信息
De Lucca A J, Bland J M, Boue S, Vigo C B, Cleveland T E, Walsh T J
机构信息
Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, La. 70124, USA.
出版信息
Chemotherapy. 2006;52(6):285-7. doi: 10.1159/000095959. Epub 2006 Sep 27.
BACKGROUND
CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT.
METHODS
CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h.
RESULTS
CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.
背景
CAY-1是一种来自辣椒的具有杀真菌作用的皂苷，其作用方式不同于两性霉素B（AB）和伊曲康唑（IT）。本研究确定了CAY-1与AB或IT的协同作用。
方法
纯化CAY-1并用于棋盘微量稀释研究，将CAY-1与AB或IT分别与三种曲霉菌和白色念珠菌的未萌发（NG）和已萌发（G）分生孢子混合。在24小时和48小时时通过肉眼观察抑制情况。
结果
CAY-1与AB或IT对曲霉菌的未萌发和已萌发分生孢子主要呈现相加-协同相互作用。在24小时和48小时时，CAY-1与AB对白色念珠菌呈现出优异的协同作用。结果表明CAY-1可增强AB和IT的疗效。
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