Salzberger B
Infektiologie, Klinik und Poliklinik I für Innere Medizin, Universitätsklinikum, Regensburg.
Internist (Berl). 2006 Dec;47(12):1245-50. doi: 10.1007/s00108-006-1721-9.
Antiviral drug therapy has rapidly evolved in recent years. A large number of specific inhibitors against newly detected viral targets has been developed. Viral infections except HIV and viral hepatitis infections are clinically relevant mostly in severely immunocompromised patients. Especially respiratory viral infections and herpes virus infections are associated with high morbidity and mortality in these patients. Therapeutic and preventive strategies have been developed for a number of these infections. There is high priority for the development of new substances for a number of viruses not yet treatable and substances active against resistant viral strains.
近年来,抗病毒药物治疗发展迅速。已开发出大量针对新发现病毒靶点的特异性抑制剂。除艾滋病毒和病毒性肝炎感染外,病毒感染在临床上主要与严重免疫功能低下的患者相关。特别是呼吸道病毒感染和疱疹病毒感染在这些患者中具有较高的发病率和死亡率。针对其中一些感染已制定了治疗和预防策略。对于许多尚未可治疗的病毒以及对耐药病毒株有活性的物质的研发具有高度优先性。