Prince H E, Jackson A L
American Red Cross Blood Services, Los Angeles, California 90006.
Clin Immunol Immunopathol. 1990 Dec;57(3):459-64. doi: 10.1016/0090-1229(90)90119-b.
Dysregulated expression of the p55 interleukin 2 receptor (CD25) is characteristic of adult T cell leukemia (ATL) associated with human T lymphotropic virus (HTLV) infection. In order to determine if similar changes characterize HTLV infection in the apparent absence of ATL, CD25 expression by peripheral blood lymphocytes from HTLV-seropositive former blood donors was measured using a sensitive dual-color cytofluorometric assay. When comparing the HTLV-seropositive group (N = 19) and a seronegative control group (N = 20), no significant differences were observed in either the proportions of the major lymphocyte subsets (CD3, CD4, CD8, CD19, CD16/56) coexpressing CD25 or the phenotypic distribution of CD25+ cells among these lymphocyte subsets. Similarly, the total percentages of CD3, CD4, CD8, and CD19 cell subsets were unchanged; however, the percentage of CD16/56+ cells was significantly decreased in the HTLV group and reflected a decrease in the percentage of CD16/56 cells lacking CD25. These findings indicate that HTLV infection without ATL is characterized by normal CD25 expression by lymphocytes and a decreased percentage of lymphocytes with a phenotype characteristic of natural killer cells.
p55白细胞介素2受体（CD25）表达失调是与人类嗜T淋巴细胞病毒（HTLV）感染相关的成人T细胞白血病（ATL）的特征。为了确定在明显无ATL的情况下HTLV感染是否具有类似变化，使用灵敏的双色细胞荧光分析测定法检测了HTLV血清反应阳性的前献血者外周血淋巴细胞的CD25表达。比较HTLV血清反应阳性组（N = 19）和血清反应阴性对照组（N = 20）时，共表达CD25的主要淋巴细胞亚群（CD3、CD4、CD8、CD19、CD16/56）比例或这些淋巴细胞亚群中CD25+细胞的表型分布均未观察到显著差异。同样，CD3、CD4、CD8和CD19细胞亚群的总百分比未改变；然而，HTLV组中CD16/56+细胞的百分比显著降低，这反映了缺乏CD25的CD16/56细胞百分比的下降。这些发现表明，无ATL的HTLV感染的特征是淋巴细胞CD25表达正常，以及具有自然杀伤细胞表型特征的淋巴细胞百分比降低。
