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扩增自然杀伤细胞(ANK)疗法治疗成人T细胞白血病/淋巴瘤(ATL)的疗效及ANK疗法的未来前景

Effectiveness of Amplified Natural Killer (ANK) Therapy for Adult T-cell Leukemia/Lymphoma (ATL) and Future Prospects of ANK Therapy.

作者信息

Nagai Kenjiro, Nagai Sho

机构信息

Ebino Centro Clinic, Ebino City, Miyazaki, Japan.

Department of Medicine, Yokohama City University School of Medicine, Yokohama, Japan.

出版信息

Cancer Med J. 2022 Jun;5(Suppl 5):27-33. Epub 2022 Mar 10.

Abstract

Amplified Natural Killer (ANK) therapy is modified to increase the safety and efficacy of the original (LAK) immunotherapy. It is a method of removing natural killer (NK) cells from the patient's own blood, culturing and amplifying the NK cells, specifically increasing their ability to attack cancer and returning them for treatment. It is generally effective against all cancers. The two cases presented here and the other treated cases show that ANK therapy is very safe and effective against ATL. Further research suggests that ANK therapy, rather than chemotherapy, is likely to be the first-line therapy for ATL. In addition, low activity of NK cells means accumulation of bacterial load. Therefore, ANK therapy with high doses of activated NK cells may be effective not only for ATL and cancer, but also for patients with chronic bacterial and viral infections.

摘要

扩增自然杀伤细胞(ANK)疗法经过改良,以提高原始(LAK)免疫疗法的安全性和有效性。它是一种从患者自身血液中提取自然杀伤(NK)细胞,进行培养和扩增,特别增强其攻击癌症的能力,然后再回输进行治疗的方法。它通常对所有癌症都有效。这里呈现的两个病例以及其他接受治疗的病例表明,ANK疗法对成人T细胞白血病/淋巴瘤(ATL)非常安全且有效。进一步的研究表明,ANK疗法而非化疗可能会成为ATL的一线治疗方法。此外,NK细胞活性低意味着细菌负荷的积累。因此,高剂量活化NK细胞的ANK疗法不仅可能对ATL和癌症有效,对慢性细菌和病毒感染患者也可能有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/891c/8986168/2a37370f7dfc/nihms-1788239-f0001.jpg

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