Xu Fei-Fei, Liu Xiu-Hua
Department of Pathophysiology, Chinese PLA General Hospital, Beijing, China.
Sheng Li Ke Xue Jin Zhan. 2006 Jul;37(3):216-20.
Calreticulin (CRT) is an essential Ca2+-binding /storage chaperone resident protein of endoplasmic reticulum or sarcoplasmic reticulum found across a diverse range of species. The protein is involved in the regulation of intracellular Ca2+ homeostasis and endoplasmic reticulum Ca2+ storage capacity, and is also an important molecular chaperone involved in "quality control" within secretory pathways. Playing an important role in apoptosis, cell adhesion, gene expression and autoimmunity, calreticulin is involved in the genesis, development and prognosis of many diseases. Now we summarized the physiological function of CRT and its expression changes during myocardial hypertrophy, heart failure, angiogenesis, stresses and many other pathological conditions.
钙网蛋白（CRT）是一种内质网或肌浆网中必需的钙离子结合/储存伴侣驻留蛋白，存在于多种物种中。该蛋白参与细胞内钙离子稳态调节和内质网钙离子储存能力，也是分泌途径中参与“质量控制”的重要分子伴侣。钙网蛋白在细胞凋亡、细胞黏附、基因表达和自身免疫中发挥重要作用，参与多种疾病的发生、发展和预后。现在我们总结了钙网蛋白的生理功能及其在心肌肥大、心力衰竭、血管生成、应激和许多其他病理状态下的表达变化。
