[钙网蛋白，内质网的钙离子结合伴侣蛋白]

[Calreticulin, Ca2+-binding chaperon of the endoplasmic reticulum].

作者信息

Szperl Małgorzata, Opas Michał

机构信息

Laboratory of Molecular Biology, Institute of Kardiology, 42 Alpejska St., 04-628 Warszawa, Poland.

出版信息

Postepy Biochem. 2005;51(4):382-6.

PMID:16676572

Abstract

The endoplasmic reticulum (ER) plays a vital role in many cellular processes, including Ca2+ storage and release. Calreticulin is a Ca2+-binding chaperon residing in ER. The protein is a key component of the quality control pathways in ER. In the ER lumen, calreticulin performs two major functions, works as a chaperon and regulates Ca2+ homeostasis. In cardiac muscle, calreticulin plays an important role in cardiac development and pathology.

摘要

内质网（ER）在许多细胞过程中发挥着至关重要的作用，包括钙离子（Ca2+）的储存和释放。钙网蛋白是一种存在于内质网中的钙离子结合伴侣蛋白。该蛋白是内质网质量控制途径的关键组成部分。在内质网腔中，钙网蛋白执行两项主要功能，作为伴侣蛋白发挥作用并调节钙离子稳态。在心肌中，钙网蛋白在心脏发育和病理过程中发挥重要作用。