Xu Chong, He Jin-Han, Xu Guo-Heng
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China.
Sheng Li Ke Xue Jin Zhan. 2006 Jul;37(3):221-4.
Perilipins are the proteins associating with the lipid droplets in adipocytes and steroidogenic cells. Unphosphorylated perilipins coat the surface of intracellular lipid droplets to form a barrier that prevents lipase from accessing to triacylglycerol core, thus suppressing lipolysis. Upon activation of protein kinase A (PKA), two proteins, hormone-sensitive lipase (HSL) and perilipins, are phosphorylated. The phosphorylated perilipin is required for inducing the translocation of HSL from the cytosol to the lipid droplets of adipocytes and is essential for the initiation of lipolytic reaction. It is proposed that phosphorylation of perilipin is a key step for the activation of lipolytic cascade via PKA and ERK signaling pathways. Dysregulation of perilipin involves in the pathogenesis of obesity, diabetes and atherosclerosis.
周脂素是与脂肪细胞和类固醇生成细胞中的脂滴相关联的蛋白质。未磷酸化的周脂素覆盖在细胞内脂滴表面，形成一道屏障，阻止脂肪酶接近三酰甘油核心，从而抑制脂肪分解。在蛋白激酶A（PKA）激活后，两种蛋白质，即激素敏感性脂肪酶（HSL）和周脂素会被磷酸化。磷酸化的周脂素是诱导HSL从细胞质转运至脂肪细胞脂滴所必需的，并且对于脂肪分解反应的启动至关重要。有人提出，周脂素的磷酸化是通过PKA和ERK信号通路激活脂肪分解级联反应的关键步骤。周脂素的失调与肥胖、糖尿病和动脉粥样硬化的发病机制有关。
