Londos C, Gruia-Gray J, Brasaemle D L, Rondinone C M, Takeda T, Dwyer N K, Barber T, Kimmel A R, Blanchette-Mackie E J
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892-2715, USA.
Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 3:S97-101.
Perilipins are a family of unique proteins intimately associated with the limiting surface of neutral lipid storage droplets in adipocytes and in steroidogenic cells. Lipid hydrolysis in these cells is initiated by cAMP, which leads to phosphorylation of hormone-sensitive lipase in adipocytes and cholesteryl esterase in steroidogenic cells by protein kinase A. Although the concurrent phosphorylation of perilipin by this kinase suggests a role for these proteins in lipid breakdown, a role for these proteins in lipid packaging or in maintaining the lipid droplet structure cannot be excluded.
围脂滴蛋白是一类独特的蛋白质，与脂肪细胞和类固醇生成细胞中中性脂质储存小滴的限制表面密切相关。这些细胞中的脂质水解由环磷酸腺苷（cAMP）启动，cAMP通过蛋白激酶A导致脂肪细胞中的激素敏感性脂肪酶和类固醇生成细胞中的胆固醇酯酶磷酸化。尽管该激酶同时使围脂滴蛋白磷酸化表明这些蛋白质在脂质分解中起作用，但不能排除这些蛋白质在脂质包装或维持脂滴结构中的作用。
