Tapsall John
World Health Organization Collaborating Centre for STD and HIV, Microbiology Department, The Prince of Wales Hospital, Sydney, Australia.
Expert Rev Anti Infect Ther. 2006 Aug;4(4):619-28. doi: 10.1586/14787210.4.4.619.
Gonorrhea is essentially out of control in many settings and high disease rates are coupled with the spread of multiresistant gonococci. Increases in quinolone resistance have followed loss of the penicillins and tetracyclines as useful treatments. Decreasing susceptibility to third-generation cephalosporins is also reported. Over-reliance on antibiotic treatment as a disease control measure in settings with high disease rates and poor control of antibiotic usage is a significant contributor to the antimicrobial resistance reported. Conversely, containment of resistance is more likely to be achieved when combined with disease control principles shown to be effective. However, until a higher priority is given to funding for sexually transmitted diseases, this prospect is unlikely to eventuate and the possibility of untreatable gonorrhea becomes more real.
淋病在许多地区基本处于失控状态，高发病率与多重耐药淋球菌的传播并存。随着青霉素和四环素不再作为有效的治疗药物，喹诺酮耐药性有所增加。也有报告称对第三代头孢菌素的敏感性在下降。在发病率高且抗生素使用控制不佳的地区，过度依赖抗生素治疗作为疾病控制措施是报告中抗菌药物耐药性的一个重要促成因素。相反，当与已证明有效的疾病控制原则相结合时，更有可能控制耐药性。然而，除非对性传播疾病的资金投入给予更高优先级，否则这种前景不太可能实现，无法治愈的淋病可能性变得更加现实。
