Johnson Steven R, Grad Yonatan, Ganakammal Satishkumar Ranganathan, Burroughs Mark, Frace Mike, Lipsitch Marc, Weil Ryan, Trees David
Division of STD Prevention, NCHHSTP, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Antimicrob Agents Chemother. 2014 Nov;58(11):6986-9. doi: 10.1128/AAC.03082-14. Epub 2014 Sep 8.
Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ.
从头孢曲松治疗失败的病例中分离出了淋病奈瑟菌菌株，这些菌株的镶嵌型penA基因在penA中带有新的点突变。此类分离株对第三代头孢菌素的最低抑菌浓度（MIC）值显著更高。在此，我们报告了两株对头孢菌素MIC升高的突变体的体外分离情况。第一株在镶嵌型penA基因的转肽酶区域存在一个点突变，第二株在pilQ中含有一个插入突变。
