Ahlgren M, Melbye M, Wohlfahrt J, Sørensen T I A
Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen S, Denmark.
Int J Gynecol Cancer. 2006;16 Suppl 2:569-75. doi: 10.1111/j.1525-1438.2006.00698.x.
Adult height and body mass index (BMI) influence the risk of breast cancer in women. Whether these associations reflect growth patterns of the fetus or growth during childhood and adolescence is unknown. We investigated the association between growth during childhood and the risk of breast cancer in a cohort of 117,415 Danish women. Birth weight, age at menarche, and annual measurements of height and weight were obtained from school health records. We used the data to model individual growth curves. Information on vital status, age at first childbirth, parity, and diagnosis of breast cancer was obtained through linkages to national registries. During 3,333,359 person-years of follow-up, 3340 cases of breast cancer were diagnosed. High birth weight, high stature at 14 years of age, low BMI at 14 years of age, and peak growth at an early age were independent risk factors for breast cancer. Height at 8 years of age and the increase in height during puberty (8-14 years of age) were also associated with breast cancer. The attributable risks of birth weight, height at 14 years of age, BMI at 14 years of age, and age at peak growth were 7%, 15%, 15%, and 9%, respectively. No effect of adjusting for age at menarche, age at first childbirth, and parity was observed. Birth weight and growth during childhood and adolescence influence the risk of breast cancer.
成年女性的身高和体重指数（BMI）会影响患乳腺癌的风险。这些关联是否反映胎儿的生长模式或儿童及青少年时期的生长情况尚不清楚。我们在117415名丹麦女性队列中调查了儿童时期的生长与乳腺癌风险之间的关联。出生体重、初潮年龄以及身高和体重的年度测量数据均来自学校健康记录。我们利用这些数据建立个体生长曲线模型。通过与国家登记处的关联，获取了生命状态、首次生育年龄、产次和乳腺癌诊断等信息。在3333359人年的随访期间，共诊断出3340例乳腺癌病例。出生体重高、14岁时身材高、14岁时BMI低以及早年生长高峰是乳腺癌的独立危险因素。8岁时的身高以及青春期（8至
