Ding Xiao-Sheng, Li Xiao-Yu, Duan Hong-Ying, Chung Ik-Kyo, Lee Jin-Ae
College of Life Science, Henan Normal University, Xin Xiang 453007, PR China.
Toxicon. 2006 Dec 15;48(8):973-9. doi: 10.1016/j.toxicon.2006.07.039. Epub 2006 Aug 22.
In this paper, the reproductive toxicity of male mice treated with Microcystis aeruginosa cell extracts containing microcystins was examined. In contrast to the control group, male mice exposed intraperitoneally to 3.33 or 6.67 microg microcystins/kg body weight for 14 days had decreased mean body weight, and the mean absolute weight of the testes and epididymides was decreased. However, the mean relative weight of the testes increased compared to the controls. In addition, histological examination of microcystin-treated mice indicated that the testes were damaged and the space between the seminiferous tubules was more pronounced compared to control mice. The quality of mature sperm in the seminiferous tubules was also decreased in treated mice compared with the control group. Further studies showed that motility and viability of the sperm from microcystin-treated mice were reduced, but no significant difference was found in the concentration and abnormality of the sperm from treated mice compared to the control. This study indicated that microcystins had numerous toxic effects on the reproductive system of male mice.
本文研究了用含有微囊藻毒素的铜绿微囊藻细胞提取物处理雄性小鼠后的生殖毒性。与对照组相比，腹腔注射3.33或6.67微克微囊藻毒素/千克体重14天的雄性小鼠平均体重下降，睾丸和附睾的平均绝对重量降低。然而，与对照组相比，睾丸的平均相对重量增加。此外，对微囊藻毒素处理小鼠的组织学检查表明，与对照小鼠相比，睾丸受损，生精小管之间的间隙更明显。与对照组相比也，处理组小鼠生精小管中成熟精子的质量也有所下降。进一步研究表明，微囊藻毒素处理小鼠的精子活力和生存能力降低，但与对照组相比，处理组小鼠精子的浓度和异常情况没有显著差异。本研究表明，微囊藻毒素对雄性小鼠的生殖系统有多种毒性作用。
