聚氰基丙烯酸正丁酯纳米粒作为丝裂霉素C在荷VX2肝癌兔体内的载体
Polybutylcyanoacrylate nanoparticles as a carrier for mitomycin C in rabbits bearing VX2-liver tumor.
作者信息
Xi-Xiao Yang, Jan-Hai Chen, Shi-Ting Liu, Dan Guo, Xv-Xin Zeng
机构信息
Department of Pharmacy, NanFan Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Regul Toxicol Pharmacol. 2006 Dec;46(3):211-7. doi: 10.1016/j.yrtph.2006.07.008. Epub 2006 Sep 28.
Polybutylcyanoacrylate nanoparticles (PBCA-NP) were prepared by addition of the monomer to an aqueous phase containing dextran 70 and loaded with mitomycin C (MMC-PBCA-NP), a highly effective anticancer drug. When injected into mice, MMC-PBCA-NP accumulated more in the liver than did free MMC. In contrast, MMC-PBCA-NP accumulated less in the heart and kidney than did free MMC. However, when MMC-PBCA-NP and MMC were administered to rabbits bearing VX2 cells implanted into the liver, the antiproliferative effects on the tumor cells of both drugs were similar. Histological analyses indicated that organization of myocardial filaments was disrupted and vacuolization was observed in the MMC treated group, whereas MMC-PBCA-NP treatment did not appear to damage the host's heart. Hydropic degeneration of renal tubular epithelia was observed in the MMC treated group and not in the control group, whereas MMC-PBCA-NP treatment did not appear to damage the host's kidney.
聚氰基丙烯酸丁酯纳米粒（PBCA-NP）是通过将单体添加到含有葡聚糖70的水相中制备的，并负载了丝裂霉素C（MMC-PBCA-NP），一种高效抗癌药物。当注射到小鼠体内时，MMC-PBCA-NP在肝脏中的积累比游离丝裂霉素C更多。相比之下，MMC-PBCA-NP在心脏和肾脏中的积累比游离丝裂霉素C更少。然而，当将MMC-PBCA-NP和丝裂霉素C给予植入VX2细胞的荷瘤兔时，两种药物对肿瘤细胞的抗增殖作用相似。组织学分析表明，丝裂霉素C治疗组观察到心肌细丝排列紊乱和空泡化，而MMC-PBCA-NP治疗似乎未损害宿主心脏。丝裂霉素C治疗组观察到肾小管上皮细胞的水样变性，而对照组未观察到，而MMC-PBCA-NP治疗似乎未损害宿主肾脏。
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