Stone Anne C, Verrelli Brian C
School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287-2402, USA.
Curr Opin Genet Dev. 2006 Dec;16(6):586-91. doi: 10.1016/j.gde.2006.09.003. Epub 2006 Sep 28.
The initial human and chimpanzee genome sequences have been published, and additional primate genomes, including those of gorilla and orang-utan, are in progress. With these new resources, we can now address what makes our species unique, by focusing on the underlying genetic differences associated with phenotypes. Comparative primate population genomics, including studies of structural changes, mobile elements, gene expression and functional analyses, will shed light on how natural selection and population demography are involved in the processes that lead to differences among great apes. Historically, this research has focused on the human perspective; however, we will learn much about ourselves with a focus on genomic diversity in hominoids as a group.
人类和黑猩猩的初始基因组序列已经公布，包括大猩猩和猩猩在内的其他灵长类动物基因组测序工作也在进行中。有了这些新资源，我们现在可以通过关注与表型相关的潜在基因差异，来探究是什么让我们的物种独一无二。比较灵长类动物群体基因组学，包括对结构变化、移动元件、基因表达和功能分析的研究，将阐明自然选择和群体人口统计学如何参与导致大猩猩之间差异的过程。从历史上看，这项研究一直侧重于人类视角；然而，通过关注作为一个群体的类人猿的基因组多样性，我们将更多地了解我们自己。
