吉非替尼相关性毛囊炎的治疗。

Treatment of gefitinib-associated folliculitis.

作者信息

Matheis Patricia, Socinski Mark A, Burkhart Craig, Warren Simon, Thomas Nancy E

机构信息

Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

出版信息

J Am Acad Dermatol. 2006 Oct;55(4):710-3. doi: 10.1016/j.jaad.2006.06.034.

DOI:10.1016/j.jaad.2006.06.034

PMID:17010757

Abstract

Gefitinib (Iressa), an epidermal growth factor inhibitor approved for treatment of advanced nonsmall cell lung carcinoma, is associated with an acneiform distributed folliculitis. Treatment attempts for this folliculitis have been noted in the literature, but photodocumentation of results has not been reported. We report 3 consecutive cases of gefitinib-associated folliculitis with photodocumentation of their treatment responses to combination therapy with topical metronidazole and oral tetracyclines.

摘要

吉非替尼（易瑞沙）是一种被批准用于治疗晚期非小细胞肺癌的表皮生长因子抑制剂，它与一种呈痤疮样分布的毛囊炎有关。文献中已提及针对这种毛囊炎的治疗尝试，但尚未有治疗结果的照片记录报道。我们报告了连续3例吉非替尼相关性毛囊炎病例，并通过照片记录了它们对局部应用甲硝唑和口服四环素联合治疗的反应。