Sathyanarayanan Vishwanath, Lokesh Kadabur Nagendrappa, Channaviriappa Lakshmaiah Kuntejowdahalli, Jacob Linu Abraham
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
Indian J Med Paediatr Oncol. 2014 Jan;35(1):109-10. doi: 10.4103/0971-5851.133736.
We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event.
我们报告一例50岁女性肺转移性腺癌患者，在开始每日服用250毫克吉非替尼2周后出现吉非替尼诱发的皮肤溃疡。停用吉非替尼2周，并加用外用类固醇和抗生素后，溃疡有所改善。我们报告此病例是为了提高肿瘤治疗医生对这种不良反应的认识，同时提示治疗中断以及外用类固醇/抗生素对治疗这一不良事件是有用的。
