Kim H Nina, Harrington Robert D
Division of Allergy and Infectious Diseases, University of Washington School of Medicine, 325 Ninth Avenue, Seattle WA 98104, USA.
Dermatol Clin. 2006 Oct;24(4):537-47, vii. doi: 10.1016/j.det.2006.06.012.
Combination antiretroviral therapy (ART) has transformed the care of individuals who have HIV infection. Effective ART has resulted in dramatic reductions in mortality, hospitalization rates, and the development of AIDS-defining illnesses. This article discusses the variety of agents that can comprise an effective ART regimen, focusing on the basic principles of ART, the indications for initiating ART in treatment-naive individuals who have established HIV infection, and the challenges associated with the use of antiretroviral medications.
联合抗逆转录病毒疗法(ART)已经改变了对感染艾滋病毒个体的护理。有效的ART已使死亡率、住院率以及艾滋病界定疾病的发生率大幅降低。本文讨论了可构成有效ART方案的各类药物,重点关注ART的基本原则、对已确诊感染艾滋病毒的初治个体启动ART的指征,以及与使用抗逆转录病毒药物相关的挑战。