Pojda Z, Aoki Y, Tsuboi A
Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba, Japan.
Immunol Cell Biol. 1990 Aug;68 ( Pt 4):231-3. doi: 10.1038/icb.1990.32.
The possible role of T lymphocytes in in vivo regulation of haemopoiesis by recombinant human granulocyte-colony stimulating factor (rhG-CSF) was evaluated. Athymic nude (nu/nu) mice and their normal (+/+) littermates were injected subcutaneously twice daily with 100 micrograms/kg per day of rhG-CSF for 5 days. Such parameters as number of neutrophils in blood, spleen weight and cellularity, bone marrow cellularity, and number of stem and progenitor cells (colony forming units in spleen [CFU-S], mix colony forming cells [Mix-CFC], granulocyte-macrophage colony forming cells [GM-CFC] in bone marrow and spleen were evaluated. Some effects of the rhG-CSF treatment were similar in nu/nu and +/+ mice. Others, however, were to some extent different in the two groups of animals. It is concluded that T lymphocytes may be partially responsible for some of the effects of rhG-CSF in vivo activity.
评估了T淋巴细胞在重组人粒细胞集落刺激因子（rhG-CSF）体内造血调节中的可能作用。无胸腺裸鼠（nu/nu）及其正常（+/+）同窝仔鼠每天皮下注射两次，每次100微克/千克的rhG-CSF，持续5天。评估了诸如血液中中性粒细胞数量、脾脏重量和细胞数量、骨髓细胞数量以及干细胞和祖细胞数量（脾脏集落形成单位[CFU-S]、混合集落形成细胞[Mix-CFC]、骨髓和脾脏中的粒细胞-巨噬细胞集落形成细胞[GM-CFC]）等参数。rhG-CSF治疗的一些效果在nu/nu小鼠和+/+小鼠中相似。然而，在两组动物中，其他一些效果在一定程度上有所不同。得出的结论是，T淋巴细胞可能部分负责rhG-CSF体内活性的某些作用。
