Rezende Renata A, Bisol Tiago, Hammersmith Kristin, Rapuano Christopher J, Lima Ana Luisa H, Webster Guy F, Freitas Juliana F, Laibson Peter R, Cohen Elisabeth J
Cornea Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Am J Ophthalmol. 2006 Oct;142(4):563-7. doi: 10.1016/j.ajo.2006.05.025.
To compare the efficacy of oral antiviral prophylactic treatment for herpes simplex virus (HSV) recurrences in patients with and without self-reported atopy.
Retrospective cohort comparative study.
setting: Cornea Service, Wills Eye Hospital. study population: Patients who presented with previously diagnosed ocular HSV between March 2003 and March 2004. From 244 patients invited, 54 patients (58 eyes) were included. One hundred and ninety patients were excluded according to exclusion criteria: no active episode during follow-up, immunosuppression, less than one year of follow-up, or previous history of penetrating keratoplasty. The Questionnaire regarding history of atopic disease, considers: presence of allergic rhinitis, asthma or atopic dermatitis, and chart review of ocular history. main outcome measures: Incidence of all types of HSV recurrences with and without antiviral prophylaxis within each group and between groups. HSV episodes were classified into infectious, inflammatory, and mixed for analysis.
Atopic/nonatopic (P value): mean follow-up without prophylaxis 8.1 (+/- 8.2)/7.3 years (+/- 8.6) (P = .71); mean follow-up with prophylaxis 2.9 (+/- 2.3)/2.6 years (+/- 2.2) (P = .51); the effect of prophylaxis significantly reduced the all recurrences in both groups except in the inflammatory recurrences in the atopic group and in the mixed recurrences in both groups. Prophylaxis decreased infectious episodes by 44% in nonatopic and 76% in atopics and decreased inflammatory manifestations by 69% in the nonatopic group and 8% in the atopic group.
Antiviral prophylaxis for HSV recurrences was more effective in reducing infections in atopics and less effective in reducing inflammatory episodes in atopics versus nonatopics.
比较口服抗病毒预防性治疗对有或无自我报告特应性的单纯疱疹病毒（HSV）复发患者的疗效。
回顾性队列比较研究。
地点：威尔斯眼科医院角膜科。研究人群：2003年3月至2004年3月期间出现先前诊断的眼部HSV的患者。在受邀的244名患者中，纳入了54名患者（58只眼）。根据排除标准排除了190名患者：随访期间无活动发作、免疫抑制、随访时间少于一年或有穿透性角膜移植术病史。关于特应性疾病史的问卷，考虑：过敏性鼻炎、哮喘或特应性皮炎的存在，以及眼部病史的图表回顾。主要观察指标：每组内及组间有或无抗病毒预防措施时各类HSV复发的发生率。HSV发作分为感染性、炎症性和混合性进行分析。
特应性/非特应性（P值）：无预防措施时的平均随访时间8.1（±8.2）/7.3年（±8.6）（P = 0.71）；有预防措施时的平均随访时间2.9（±2.3）/2.6年（±2.2）（P = 0.51）；预防措施的效果显著降低了两组中的所有复发率，但特应性组的炎症性复发和两组中的混合性复发除外。预防措施使非特应性组的感染性发作减少了44%，特应性组减少了76%，非特应性组的炎症表现减少了69%，特应性组减少了8%。
抗病毒预防HSV复发在减少特应性患者的感染方面更有效，而在减少特应性患者与非特应性患者的炎症发作方面效果较差。
